"With Or Without You" is the seventeenth episode of the eleventh season of Grey's Anatomy and the 237th produced episode of the series. It is also the 348th produced episode of the Grey's Anatomy franchise. It was broadcast on March 26, 2015.
With the future of her marriage uncertain after Derek's return, Meredith pushes for a risky procedure for one of Alex's patients as she tries to distract herself from the issues in her relationship as flashbacks reveal Derek's life in D.C. Owen's mother is admitted to the E.R, accompanied by her much younger partner, which angers Owen who, in turn, lashes out at Amelia, questioning their budding romance. Jo diagnoses a patient with a leech in her sinus cavity while Stephanie worries she's placed too much focus on neuro.
- "There's this thing I used to do when I was a kid to my mom's VCR, I'd take it apart, piece by piece, then I'd put it back together again. But, inevitably, there was always a piece or two left over. Something I didn't quite know what to do with. So what do you do with that piece? Do you try to fit it back in? Do you try to make it work? Or do you decide you can live without that missing piece?"
- "When we go without certain things for long enough it's easy to forget just how much we need them. We forget what we had once, we forget what it's like to live with that thing not that we need, but that we want. That's why it's so important for us to remind ourselves, for us to remember. Just because we can live without something, it doesn't mean we have to."
- "Build It Better" - Aron Wright
This episode's title originated from the song With Or Without You, originally sung by U2.